RapamycinFungusV1, Main, Exploration, bibRecord, 001001

Ptc6 is required for proper rapamycin-induced down-regulation of the genes coding for ribosomal and rRNA processing proteins in S. cerevisiae.

Identifieur interne : 001001 ( Main/Exploration ); précédent : 001000; suivant : 001002

Ptc6 is required for proper rapamycin-induced down-regulation of the genes coding for ribosomal and rRNA processing proteins in S. cerevisiae.

Auteurs : Asier González [Espagne] ; Carlos Casado ; Joaquín Ari O ; Antonio Casamayor

Source :

PloS one [ 1932-6203 ] ; 2013.

RBID : pubmed:23704987

Descripteurs français

English descriptors

KwdEn :
- Down-Regulation (drug effects), Down-Regulation (genetics), Epistasis, Genetic (drug effects), Gene Expression Regulation, Fungal (drug effects), Genes, Fungal (genetics), Glucose (pharmacology), Mitophagy (drug effects), Mitophagy (genetics), Mutation (genetics), Phenotype (MeSH), Phosphoprotein Phosphatases (metabolism), Phosphorylation (drug effects), Promoter Regions, Genetic (genetics), RNA Processing, Post-Transcriptional (drug effects), RNA, Ribosomal (metabolism), Ribosomes (drug effects), Ribosomes (metabolism), Saccharomyces cerevisiae (drug effects), Saccharomyces cerevisiae (genetics), Saccharomyces cerevisiae (growth & development), Saccharomyces cerevisiae Proteins (genetics), Saccharomyces cerevisiae Proteins (metabolism), Signal Transduction (drug effects), Signal Transduction (genetics), Sirolimus (pharmacology).
MESH :
- chemical , genetics : Saccharomyces cerevisiae Proteins.
- chemical , metabolism : Phosphoprotein Phosphatases, RNA, Ribosomal, Saccharomyces cerevisiae Proteins.
- chemical , pharmacology : Glucose, Sirolimus.
- drug effects : Down-Regulation, Epistasis, Genetic, Gene Expression Regulation, Fungal, Mitophagy, Phosphorylation, RNA Processing, Post-Transcriptional, Ribosomes, Saccharomyces cerevisiae, Signal Transduction.
- genetics : Down-Regulation, Genes, Fungal, Mitophagy, Mutation, Promoter Regions, Genetic, Saccharomyces cerevisiae, Signal Transduction.
- growth & development : Saccharomyces cerevisiae.
- metabolism : Ribosomes.
- Phenotype.

Abstract

Ptc6 is one of the seven components (Ptc1-Ptc7) of the protein phosphatase 2C family in the yeast Saccharomyces cerevisiae. In contrast to other type 2C phosphatases, the cellular role of this isoform is poorly understood. We present here a comprehensive characterization of this gene product. Cells lacking Ptc6 are sensitive to zinc ions, and somewhat tolerant to cell-wall damaging agents and to Li(+). Ptc6 mutants are sensitive to rapamycin, albeit to lesser extent than ptc1 cells. This phenotype is not rescued by overexpression of PTC1 and mutation of ptc6 does not reproduce the characteristic genetic interactions of the ptc1 mutation with components of the TOR pathway, thus suggesting different cellular roles for both isoforms. We show here that the rapamycin-sensitive phenotype of ptc6 cells is unrelated to the reported role of Pt6 in controlling pyruvate dehydrogenase activity. Lack of Ptc6 results in substantial attenuation of the transcriptional response to rapamycin, particularly in the subset of repressed genes encoding ribosomal proteins or involved in rRNA processing. In contrast, repressed genes involved in translation are Ptc6-independent. These effects cannot be attributed to the regulation of the Sch9 kinase, but they could involve modulation of the binding of the Ifh1 co-activator to specific gene promoters.

DOI: 10.1371/journal.pone.0064470
PubMed: 23704987
PubMed Central: PMC3660562

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 001025
to stream Main, to step Curation: 001025

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Ptc6 is required for proper rapamycin-induced down-regulation of the genes coding for ribosomal and rRNA processing proteins in S. cerevisiae.</title>
<author><name sortKey="Gonzalez, Asier" sort="Gonzalez, Asier" uniqKey="Gonzalez A" first="Asier" last="González">Asier González</name>
<affiliation wicri:level="4"><nlm:affiliation>Institut de Biotecnologia i Biomedicina (IBB) and Departament de Bioquímica i Biologia Molecular, Facultat de Veterinària, Universitat Autònoma de Barcelona, Cerdanyola del Vallès, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Institut de Biotecnologia i Biomedicina (IBB) and Departament de Bioquímica i Biologia Molecular, Facultat de Veterinària, Universitat Autònoma de Barcelona, Cerdanyola del Vallès</wicri:regionArea>
<orgName type="university">Université autonome de Barcelone</orgName>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Casado, Carlos" sort="Casado, Carlos" uniqKey="Casado C" first="Carlos" last="Casado">Carlos Casado</name>
</author>
<author><name sortKey="Ari O, Joaquin" sort="Ari O, Joaquin" uniqKey="Ari O J" first="Joaquín" last="Ari O">Joaquín Ari O</name>
</author>
<author><name sortKey="Casamayor, Antonio" sort="Casamayor, Antonio" uniqKey="Casamayor A" first="Antonio" last="Casamayor">Antonio Casamayor</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2013">2013</date>
<idno type="RBID">pubmed:23704987</idno>
<idno type="pmid">23704987</idno>
<idno type="doi">10.1371/journal.pone.0064470</idno>
<idno type="pmc">PMC3660562</idno>
<idno type="wicri:Area/Main/Corpus">001025</idno>
<idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">001025</idno>
<idno type="wicri:Area/Main/Curation">001025</idno>
<idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">001025</idno>
<idno type="wicri:Area/Main/Exploration">001025</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Ptc6 is required for proper rapamycin-induced down-regulation of the genes coding for ribosomal and rRNA processing proteins in S. cerevisiae.</title>
<author><name sortKey="Gonzalez, Asier" sort="Gonzalez, Asier" uniqKey="Gonzalez A" first="Asier" last="González">Asier González</name>
<affiliation wicri:level="4"><nlm:affiliation>Institut de Biotecnologia i Biomedicina (IBB) and Departament de Bioquímica i Biologia Molecular, Facultat de Veterinària, Universitat Autònoma de Barcelona, Cerdanyola del Vallès, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Institut de Biotecnologia i Biomedicina (IBB) and Departament de Bioquímica i Biologia Molecular, Facultat de Veterinària, Universitat Autònoma de Barcelona, Cerdanyola del Vallès</wicri:regionArea>
<orgName type="university">Université autonome de Barcelone</orgName>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Casado, Carlos" sort="Casado, Carlos" uniqKey="Casado C" first="Carlos" last="Casado">Carlos Casado</name>
</author>
<author><name sortKey="Ari O, Joaquin" sort="Ari O, Joaquin" uniqKey="Ari O J" first="Joaquín" last="Ari O">Joaquín Ari O</name>
</author>
<author><name sortKey="Casamayor, Antonio" sort="Casamayor, Antonio" uniqKey="Casamayor A" first="Antonio" last="Casamayor">Antonio Casamayor</name>
</author>
</analytic>
<series><title level="j">PloS one</title>
<idno type="eISSN">1932-6203</idno>
<imprint><date when="2013" type="published">2013</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Down-Regulation (drug effects)</term>
<term>Down-Regulation (genetics)</term>
<term>Epistasis, Genetic (drug effects)</term>
<term>Gene Expression Regulation, Fungal (drug effects)</term>
<term>Genes, Fungal (genetics)</term>
<term>Glucose (pharmacology)</term>
<term>Mitophagy (drug effects)</term>
<term>Mitophagy (genetics)</term>
<term>Mutation (genetics)</term>
<term>Phenotype (MeSH)</term>
<term>Phosphoprotein Phosphatases (metabolism)</term>
<term>Phosphorylation (drug effects)</term>
<term>Promoter Regions, Genetic (genetics)</term>
<term>RNA Processing, Post-Transcriptional (drug effects)</term>
<term>RNA, Ribosomal (metabolism)</term>
<term>Ribosomes (drug effects)</term>
<term>Ribosomes (metabolism)</term>
<term>Saccharomyces cerevisiae (drug effects)</term>
<term>Saccharomyces cerevisiae (genetics)</term>
<term>Saccharomyces cerevisiae (growth & development)</term>
<term>Saccharomyces cerevisiae Proteins (genetics)</term>
<term>Saccharomyces cerevisiae Proteins (metabolism)</term>
<term>Signal Transduction (drug effects)</term>
<term>Signal Transduction (genetics)</term>
<term>Sirolimus (pharmacology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>ARN ribosomique (métabolisme)</term>
<term>Glucose (pharmacologie)</term>
<term>Gènes fongiques (génétique)</term>
<term>Maturation post-transcriptionnelle des ARN (effets des médicaments et des substances chimiques)</term>
<term>Mutation (génétique)</term>
<term>Phosphoprotein Phosphatases (métabolisme)</term>
<term>Phosphorylation (effets des médicaments et des substances chimiques)</term>
<term>Phénotype (MeSH)</term>
<term>Protéines de Saccharomyces cerevisiae (génétique)</term>
<term>Protéines de Saccharomyces cerevisiae (métabolisme)</term>
<term>Ribosomes (effets des médicaments et des substances chimiques)</term>
<term>Ribosomes (métabolisme)</term>
<term>Régions promotrices (génétique) (génétique)</term>
<term>Régulation de l'expression des gènes fongiques (effets des médicaments et des substances chimiques)</term>
<term>Régulation négative (effets des médicaments et des substances chimiques)</term>
<term>Régulation négative (génétique)</term>
<term>Saccharomyces cerevisiae (croissance et développement)</term>
<term>Saccharomyces cerevisiae (effets des médicaments et des substances chimiques)</term>
<term>Saccharomyces cerevisiae (génétique)</term>
<term>Sirolimus (pharmacologie)</term>
<term>Transduction du signal (effets des médicaments et des substances chimiques)</term>
<term>Transduction du signal (génétique)</term>
<term>Épistasie (effets des médicaments et des substances chimiques)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Saccharomyces cerevisiae Proteins</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Phosphoprotein Phosphatases</term>
<term>RNA, Ribosomal</term>
<term>Saccharomyces cerevisiae Proteins</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Glucose</term>
<term>Sirolimus</term>
</keywords>
<keywords scheme="MESH" qualifier="croissance et développement" xml:lang="fr"><term>Saccharomyces cerevisiae</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Down-Regulation</term>
<term>Epistasis, Genetic</term>
<term>Gene Expression Regulation, Fungal</term>
<term>Mitophagy</term>
<term>Phosphorylation</term>
<term>RNA Processing, Post-Transcriptional</term>
<term>Ribosomes</term>
<term>Saccharomyces cerevisiae</term>
<term>Signal Transduction</term>
</keywords>
<keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Maturation post-transcriptionnelle des ARN</term>
<term>Phosphorylation</term>
<term>Ribosomes</term>
<term>Régulation de l'expression des gènes fongiques</term>
<term>Régulation négative</term>
<term>Saccharomyces cerevisiae</term>
<term>Transduction du signal</term>
<term>Épistasie</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Down-Regulation</term>
<term>Genes, Fungal</term>
<term>Mitophagy</term>
<term>Mutation</term>
<term>Promoter Regions, Genetic</term>
<term>Saccharomyces cerevisiae</term>
<term>Signal Transduction</term>
</keywords>
<keywords scheme="MESH" qualifier="growth & development" xml:lang="en"><term>Saccharomyces cerevisiae</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Gènes fongiques</term>
<term>Mutation</term>
<term>Protéines de Saccharomyces cerevisiae</term>
<term>Régions promotrices (génétique)</term>
<term>Régulation négative</term>
<term>Saccharomyces cerevisiae</term>
<term>Transduction du signal</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Ribosomes</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>ARN ribosomique</term>
<term>Phosphoprotein Phosphatases</term>
<term>Protéines de Saccharomyces cerevisiae</term>
<term>Ribosomes</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Glucose</term>
<term>Sirolimus</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Phenotype</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Phénotype</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Ptc6 is one of the seven components (Ptc1-Ptc7) of the protein phosphatase 2C family in the yeast Saccharomyces cerevisiae. In contrast to other type 2C phosphatases, the cellular role of this isoform is poorly understood. We present here a comprehensive characterization of this gene product. Cells lacking Ptc6 are sensitive to zinc ions, and somewhat tolerant to cell-wall damaging agents and to Li(+). Ptc6 mutants are sensitive to rapamycin, albeit to lesser extent than ptc1 cells. This phenotype is not rescued by overexpression of PTC1 and mutation of ptc6 does not reproduce the characteristic genetic interactions of the ptc1 mutation with components of the TOR pathway, thus suggesting different cellular roles for both isoforms. We show here that the rapamycin-sensitive phenotype of ptc6 cells is unrelated to the reported role of Pt6 in controlling pyruvate dehydrogenase activity. Lack of Ptc6 results in substantial attenuation of the transcriptional response to rapamycin, particularly in the subset of repressed genes encoding ribosomal proteins or involved in rRNA processing. In contrast, repressed genes involved in translation are Ptc6-independent. These effects cannot be attributed to the regulation of the Sch9 kinase, but they could involve modulation of the binding of the Ifh1 co-activator to specific gene promoters.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">23704987</PMID>
<DateCompleted><Year>2013</Year>
<Month>12</Month>
<Day>30</Day>
</DateCompleted>
<DateRevised><Year>2019</Year>
<Month>12</Month>
<Day>10</Day>
</DateRevised>
<Article PubModel="Electronic-Print"><Journal><ISSN IssnType="Electronic">1932-6203</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>8</Volume>
<Issue>5</Issue>
<PubDate><Year>2013</Year>
</PubDate>
</JournalIssue>
<Title>PloS one</Title>
<ISOAbbreviation>PLoS One</ISOAbbreviation>
</Journal>
<ArticleTitle>Ptc6 is required for proper rapamycin-induced down-regulation of the genes coding for ribosomal and rRNA processing proteins in S. cerevisiae.</ArticleTitle>
<Pagination><MedlinePgn>e64470</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1371/journal.pone.0064470</ELocationID>
<Abstract><AbstractText>Ptc6 is one of the seven components (Ptc1-Ptc7) of the protein phosphatase 2C family in the yeast Saccharomyces cerevisiae. In contrast to other type 2C phosphatases, the cellular role of this isoform is poorly understood. We present here a comprehensive characterization of this gene product. Cells lacking Ptc6 are sensitive to zinc ions, and somewhat tolerant to cell-wall damaging agents and to Li(+). Ptc6 mutants are sensitive to rapamycin, albeit to lesser extent than ptc1 cells. This phenotype is not rescued by overexpression of PTC1 and mutation of ptc6 does not reproduce the characteristic genetic interactions of the ptc1 mutation with components of the TOR pathway, thus suggesting different cellular roles for both isoforms. We show here that the rapamycin-sensitive phenotype of ptc6 cells is unrelated to the reported role of Pt6 in controlling pyruvate dehydrogenase activity. Lack of Ptc6 results in substantial attenuation of the transcriptional response to rapamycin, particularly in the subset of repressed genes encoding ribosomal proteins or involved in rRNA processing. In contrast, repressed genes involved in translation are Ptc6-independent. These effects cannot be attributed to the regulation of the Sch9 kinase, but they could involve modulation of the binding of the Ifh1 co-activator to specific gene promoters.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>González</LastName>
<ForeName>Asier</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Institut de Biotecnologia i Biomedicina (IBB) and Departament de Bioquímica i Biologia Molecular, Facultat de Veterinària, Universitat Autònoma de Barcelona, Cerdanyola del Vallès, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Casado</LastName>
<ForeName>Carlos</ForeName>
<Initials>C</Initials>
</Author>
<Author ValidYN="Y"><LastName>Ariño</LastName>
<ForeName>Joaquín</ForeName>
<Initials>J</Initials>
</Author>
<Author ValidYN="Y"><LastName>Casamayor</LastName>
<ForeName>Antonio</ForeName>
<Initials>A</Initials>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2013</Year>
<Month>05</Month>
<Day>21</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>PLoS One</MedlineTA>
<NlmUniqueID>101285081</NlmUniqueID>
<ISSNLinking>1932-6203</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D012335">RNA, Ribosomal</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D029701">Saccharomyces cerevisiae Proteins</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 3.1.3.16</RegistryNumber>
<NameOfSubstance UI="C518822">PTC6 protein, S cerevisiae</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 3.1.3.16</RegistryNumber>
<NameOfSubstance UI="D010749">Phosphoprotein Phosphatases</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>IY9XDZ35W2</RegistryNumber>
<NameOfSubstance UI="D005947">Glucose</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>W36ZG6FT64</RegistryNumber>
<NameOfSubstance UI="D020123">Sirolimus</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D015536" MajorTopicYN="N">Down-Regulation</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004843" MajorTopicYN="N">Epistasis, Genetic</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015966" MajorTopicYN="N">Gene Expression Regulation, Fungal</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005800" MajorTopicYN="N">Genes, Fungal</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005947" MajorTopicYN="N">Glucose</DescriptorName>
<QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D063306" MajorTopicYN="N">Mitophagy</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009154" MajorTopicYN="N">Mutation</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010641" MajorTopicYN="N">Phenotype</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010749" MajorTopicYN="N">Phosphoprotein Phosphatases</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010766" MajorTopicYN="N">Phosphorylation</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011401" MajorTopicYN="N">Promoter Regions, Genetic</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012323" MajorTopicYN="N">RNA Processing, Post-Transcriptional</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012335" MajorTopicYN="N">RNA, Ribosomal</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012270" MajorTopicYN="N">Ribosomes</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012441" MajorTopicYN="N">Saccharomyces cerevisiae</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
<QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
<QualifierName UI="Q000254" MajorTopicYN="N">growth & development</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D029701" MajorTopicYN="N">Saccharomyces cerevisiae Proteins</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015398" MajorTopicYN="N">Signal Transduction</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D020123" MajorTopicYN="N">Sirolimus</DescriptorName>
<QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName>
</MeshHeading>
</MeshHeadingList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2012</Year>
<Month>10</Month>
<Day>05</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2013</Year>
<Month>04</Month>
<Day>16</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2013</Year>
<Month>5</Month>
<Day>25</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2013</Year>
<Month>5</Month>
<Day>25</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2014</Year>
<Month>1</Month>
<Day>1</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>epublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">23704987</ArticleId>
<ArticleId IdType="doi">10.1371/journal.pone.0064470</ArticleId>
<ArticleId IdType="pii">PONE-D-12-30826</ArticleId>
<ArticleId IdType="pmc">PMC3660562</ArticleId>
</ArticleIdList>
<ReferenceList><Reference><Citation>Nat Biotechnol. 2004 Jan;22(1):62-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">14661025</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell. 2004 Dec 29;119(7):969-79</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15620355</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 2004 Oct 15;279(42):43614-24</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15299026</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nucleic Acids Res. 2004;32(18):5539-45</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15486203</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Genes Dev. 2004 Oct 15;18(20):2491-505</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15466158</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Int Microbiol. 2004 Sep;7(3):199-206</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15492934</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 1995 Jun 2;270(22):13036-41</Citation>
<ArticleIdList><ArticleId IdType="pubmed">7768897</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mol Microbiol. 1997 Jan;23(1):57-62</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9004220</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Yeast. 1996 Dec;12(16):1647-75</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9123967</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 2005 May 17;102(20):7215-20</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15883373</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Microbiol Mol Biol Rev. 2006 Mar;70(1):177-91</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16524922</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>FEBS Lett. 2006 May 15;580(11):2553-60</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16643908</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mol Microbiol. 2006 Oct;62(1):263-77</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16956380</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 2006 Nov 17;281(46):35057-69</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16973600</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 2007 Feb 23;282(8):5617-24</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17166847</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>FEMS Yeast Res. 2007 Mar;7(2):209-15</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17002782</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mol Cell. 2007 Jun 8;26(5):663-74</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17560372</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mol Cell Biol. 2007 Jul;27(13):4815-24</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17452446</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Genetics. 2007 Aug;176(4):2139-50</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17565946</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Yeast. 1999 Nov;15(15):1669-79</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10572263</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Genes Dev. 1999 Nov 15;13(22):2946-57</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10580002</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Bacteriol. 2000 Jan;182(2):394-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10629185</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biotechniques. 2000 Sep;29(3):548-50, 552-4, 556 passim</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10997270</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mol Biol Cell. 2001 Feb;12(2):323-37</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11179418</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Bioinformatics. 2001 Feb;17(2):126-36</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11238068</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>IUBMB Life. 2000 Dec;50(6):371-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11327310</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nucleic Acids Res. 2002 Jan 1;30(1):207-10</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11752295</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Yeast. 2002 May;19(7):587-99</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11967829</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mol Cell. 2002 Sep;10(3):457-68</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12408816</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Yeast. 2003 Jan 30;20(2):157-69</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12518319</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nature. 2003 Oct 16;425(6959):686-91</Citation>
<ArticleIdList><ArticleId IdType="pubmed">14562095</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13207-12</Citation>
<ArticleIdList><ArticleId IdType="pubmed">14576278</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nucleic Acids Res. 2004 Jan 1;32(Database issue):D311-4</Citation>
<ArticleIdList><ArticleId IdType="pubmed">14681421</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 2008 Apr 11;283(15):9759-67</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18180296</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 2008 May 16;283(20):13923-33</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18362157</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 2009 Apr 17;284(16):10901-11</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19234305</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mol Cell Biol. 2009 May;29(10):2876-88</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19273591</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Genetics. 2009 Sep;183(1):185-94</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19564484</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 2009 Dec 18;284(51):35885-95</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19840933</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biochem J. 2010 Mar 15;426(3):355-64</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20028335</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nucleic Acids Res. 2011 Jan;39(Database issue):D136-40</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20972212</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Eukaryot Cell. 2011 Jan;10(1):21-33</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21076010</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Cell Sci. 2011 Apr 15;124(Pt 8):1339-50</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21429936</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Pept Sci. 2011 May;17(5):392-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21480437</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Antioxid Redox Signal. 2011 May 15;14(10):2003-11</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21194383</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>EMBO J. 2011 Aug 3;30(15):3052-64</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21730963</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Genetics. 2011 Dec;189(4):1177-201</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22174183</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Database (Oxford). 2012;2012:bar062</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22434830</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biochem J. 2012 May 15;444(1):39-49</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22372618</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Science. 1999 Aug 6;285(5429):901-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10436161</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Yeast. 1999 Oct;15(14):1541-53</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10514571</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biochem. 2004 Sep;136(3):267-72</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15598881</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nature. 2004 Dec 23;432(7020):1058-61</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15616569</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 2004 Sep 10;279(37):39068-74</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15247238</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>Espagne</li>
</country>
<region><li>Catalogne</li>
</region>
<settlement><li>Barcelone</li>
</settlement>
<orgName><li>Université autonome de Barcelone</li>
</orgName>
</list>
<tree><noCountry><name sortKey="Ari O, Joaquin" sort="Ari O, Joaquin" uniqKey="Ari O J" first="Joaquín" last="Ari O">Joaquín Ari O</name>
<name sortKey="Casado, Carlos" sort="Casado, Carlos" uniqKey="Casado C" first="Carlos" last="Casado">Carlos Casado</name>
<name sortKey="Casamayor, Antonio" sort="Casamayor, Antonio" uniqKey="Casamayor A" first="Antonio" last="Casamayor">Antonio Casamayor</name>
</noCountry>
<country name="Espagne"><region name="Catalogne"><name sortKey="Gonzalez, Asier" sort="Gonzalez, Asier" uniqKey="Gonzalez A" first="Asier" last="González">Asier González</name>
</region>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Bois/explor/RapamycinFungusV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001001 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001001 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Bois
   |area=    RapamycinFungusV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     pubmed:23704987
   |texte=   Ptc6 is required for proper rapamycin-induced down-regulation of the genes coding for ribosomal and rRNA processing proteins in S. cerevisiae.
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:23704987" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a RapamycinFungusV1

This area was generated with Dilib version V0.6.38.
Data generation: Thu Nov 19 21:55:41 2020. Site generation: Thu Nov 19 22:00:39 2020

	Serveur d'exploration sur la rapamycine et les champignons
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration sur la rapamycine et les champignons

Ptc6 is required for proper rapamycin-induced down-regulation of the genes coding for ribosomal and rRNA processing proteins in S. cerevisiae.

Ptc6 is required for proper rapamycin-induced down-regulation of the genes coding for ribosomal and rRNA processing proteins in S. cerevisiae.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki